ABCB1 ATP-binding cassette subfamily B member 1 (P-glycoprotein)
ABCB1 (ATP-binding cassette subfamily B member 1 (P-glycoprotein)): 16 variants described, covering drug response, health risk, trait.
Which ABCB1 variants does Orviva describe?
- rs1045642 Drug response
- ABCB1 3435C>T homozygous. Reduced P-glycoprotein expression; increased bioavailability of many drugs including digoxin, statins, and antiretrovirals.
15 further ABCB1 variants in the knowledge base have only a brief annotation and are not listed here.
See your own ABCB1 genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my ABCB1 variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my ABCB1 variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.