ABCG2 ATP-binding cassette subfamily G member 2
ABCG2 (ATP-binding cassette subfamily G member 2): 38 variants described, covering health risk, nutrition, trait, drug response.
Which ABCG2 variants does Orviva describe?
- rs2231142 Health risk
- ABCG2 Q141K homozygous. Significantly elevated uric acid levels and gout risk. Especially common in East Asian populations.
- rs1481012 Health risk imported
- G allele associated with slightly increased risk of Hyperuricemia in low vitamin C intake (OR=1.48). [GWAS Catalog]
- rs2199936 Health risk imported
- A allele associated with decreased risk of Serum uric acid levels (OR=0.11). [GWAS Catalog]
- rs4148155 Nutrition imported
- G allele associated with slightly increased risk of Hyperuricemia in low folate intake (OR=1.49). [GWAS Catalog]
34 further ABCG2 variants in the knowledge base have only a brief annotation and are not listed here.
See your own ABCG2 genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my ABCG2 variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my ABCG2 variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.