APOE Apolipoprotein E
APOE (Apolipoprotein E): 15 variants described, covering health risk, drug response, trait; nutrient interactions.
Which APOE variants does Orviva describe?
- rs429358 Health risk
- APOE e4/e4 homozygous. Substantially elevated risk for late-onset Alzheimer's disease (up to 12x).
- rs7412 Health risk
- APOE e2/e2. Protective against Alzheimer's but increased risk for type III hyperlipoproteinemia.
- rs440446 Health risk imported
- G allele associated with moderately increased risk of Alzheimer's disease (onset between ages 58 and 79) (OR=1.64). [GWAS Catalog]
- rs769449 Trait imported
- A allele associated with increased Longevity (β=0.058). [GWAS Catalog]
- rs769450 Trait imported
- G allele associated with increased Hand grip strength (baseline) (β=0.008). [GWAS Catalog]
10 further APOE variants in the knowledge base have only a brief annotation and are not listed here.
Which nutrients interact with APOE variants?
- DHA moderate evidence
- APOE ε4 carriers have altered brain lipid metabolism; DHA supports neuronal membrane integrity and may attenuate Alzheimer's risk
Often considered alongside: phosphatidylserine, curcumin, vitamin E.
Lab markers that reflect this pathway: TC, LDL-C, HDL-C, TG.
Dose ranges are deliberately not shown here; they depend on genotype, current levels and other medicines.
See your own APOE genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my APOE variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my APOE variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.