CFH Complement factor H
CFH (Complement factor H): 38 variants described, covering health risk, drug response, nutrition, trait.
Which CFH variants does Orviva describe?
- rs1061170 Health risk
- Significantly increased risk for age-related macular degeneration (AMD). CFH Y402H variant.
- rs10922100 Drug response imported
- G allele associated with decreased risk of Delta-like protein 3 level in Chronic kidney disease with hypertension and no... (OR=0.48). [GWAS Catalog]
- rs4658046 Nutrition imported
- C allele associated with slightly increased risk of Early age-related macular degeneration (OR=1.38). [GWAS Catalog]
35 further CFH variants in the knowledge base have only a brief annotation and are not listed here.
See your own CFH genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my CFH variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my CFH variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.