COMT Catechol-O-methyltransferase
COMT (Catechol-O-methyltransferase): 13 variants described, covering drug response, trait; nutrient interactions.
Which COMT variants does Orviva describe?
- rs4680 Trait
- COMT Val158Met Met/Met. Lower COMT activity; higher dopamine levels. Associated with increased pain sensitivity, better memory, but higher stress vulnerability.
12 further COMT variants in the knowledge base have only a brief annotation and are not listed here.
Which nutrients interact with COMT variants?
- magnesium glycinate moderate evidence
- COMT Val158Met affects catecholamine metabolism; magnesium is a key cofactor for COMT enzyme function
Often considered alongside: pyridoxal-5-phosphate, methylfolate.
Lab markers that reflect this pathway: MAGNESIUM.
Dose ranges are deliberately not shown here; they depend on genotype, current levels and other medicines.
See your own COMT genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my COMT variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my COMT variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.