CYP1A2 Cytochrome P450 1A2
CYP1A2 (Cytochrome P450 1A2): 2 variants described, covering drug response, trait; CPIC pharmacogenomic guidance available.
CYP1A2 and medicines
CYP1A2 is a pharmacogene with CPIC guidance. Star alleles, metaboliser phenotypes and the drugs affected are on the CYP1A2 pharmacogenomics page.
Which CYP1A2 variants does Orviva describe?
- rs762551 Trait
- Fast caffeine metabolizer. Can process caffeine quickly; moderate coffee consumption may be cardioprotective.
1 further CYP1A2 variant in the knowledge base has only a brief annotation and is not listed here.
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my CYP1A2 variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.