CYP2B6 Cytochrome P450 2B6
CYP2B6 (Cytochrome P450 2B6): 5 variants described, covering trait, drug response.
Which CYP2B6 variants does Orviva describe?
- rs3745274 Drug response
- CYP2B6*6 homozygous slow metabolizer. Increased efavirenz levels; higher risk of CNS side effects. Dose reduction recommended.
- rs28399499 Drug response imported
- CYP2B6 *18 carrier. No enzyme function from this allele. More common in African populations.
3 further CYP2B6 variants in the knowledge base have only a brief annotation and are not listed here.
See your own CYP2B6 genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my CYP2B6 variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my CYP2B6 variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.