DPYD Dihydropyrimidine dehydrogenase
DPYD (Dihydropyrimidine dehydrogenase): 36 variants described, covering health risk, trait, nutrition, drug response.
Which DPYD variants does Orviva describe?
- rs3918290 Drug response
- DPYD*2A homozygous. Complete DPD deficiency; 5-FU/capecitabine contraindicated due to severe/fatal toxicity risk.
- rs1801265 Drug response imported
- Genotype GG is associated with decreased metabolism of fluorouracil in people with Neoplasms as compared to genotypes AA + AG.
- rs55886062 Drug response imported
- DPYD *13 carrier. Increased risk of fluoropyrimidine toxicity.
- rs56038477 Drug response imported
- DPYD HapB3 carrier. Decreased enzyme function; dose reduction recommended for fluoropyrimidines.
- rs67376798 Drug response imported
- DPYD c.2846A>T homozygous. Significantly decreased enzyme function.
- rs7531138 Trait imported
- A allele associated with increased Educational attainment (β=0.007). [GWAS Catalog]
- rs75641275 Trait imported
- A allele associated with increased Body mass index (MTAG) (β=0.022). [GWAS Catalog]
29 further DPYD variants in the knowledge base have only a brief annotation and are not listed here.
See your own DPYD genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my DPYD variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my DPYD variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.