MAPT MAPT
MAPT (MAPT): 52 variants described, covering trait, health risk, nutrition.
Which MAPT variants does Orviva describe?
- rs1991556 Nutrition imported
- G allele associated with increased Sleep duration (β=0.016). [GWAS Catalog]
- rs242557 Health risk imported
- G allele associated with moderately increased risk of Progressive supranuclear palsy (OR=1.91). [GWAS Catalog]
- rs242559 Trait imported
- A allele associated with substantially increased risk of General cognitive ability (OR=7.43). [GWAS Catalog]
- rs8067056 Trait imported
- T allele associated with increased Body mass index (BMI, maximum, inv-normal transformed) (β=0.025). [GWAS Catalog]
48 further MAPT variants in the knowledge base have only a brief annotation and are not listed here.
See your own MAPT genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my MAPT variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my MAPT variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.