MTR Methionine synthase
MTR (Methionine synthase): 3 variants described, covering nutrition, drug response; nutrient interactions.
Which MTR variants does Orviva describe?
No variant with a full description yet.
3 further MTR variants in the knowledge base have only a brief annotation and are not listed here.
Which nutrients interact with MTR variants?
- methylcobalamin moderate evidence
- MTR A2756G reduces methionine synthase activity, increasing B12 requirement for methylation
Often considered alongside: methylfolate, pyridoxal-5-phosphate.
Lab markers that reflect this pathway: B12, HCY, MMA.
Dose ranges are deliberately not shown here; they depend on genotype, current levels and other medicines.
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my MTR variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.