MTRR Methionine synthase reductase
MTRR (Methionine synthase reductase): 4 variants described, covering nutrition, drug response, trait; nutrient interactions.
Which MTRR variants does Orviva describe?
- rs1801394 Nutrition
- MTRR A66G homozygous. Reduced methionine synthase reductase activity; may increase homocysteine and affect B12 utilization.
3 further MTRR variants in the knowledge base have only a brief annotation and are not listed here.
Which nutrients interact with MTRR variants?
- methylcobalamin moderate evidence
- MTRR A66G reduces regeneration of active B12 cofactor for methionine synthase
Often considered alongside: methylfolate, riboflavin.
Lab markers that reflect this pathway: B12, HCY.
Dose ranges are deliberately not shown here; they depend on genotype, current levels and other medicines.
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my MTRR variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.