PTPN11 PTPN11
PTPN11 (PTPN11): 12 variants described, covering health risk, nutrition, drug response, trait.
Which PTPN11 variants does Orviva describe?
- rs11066309 Health risk imported
- G allele associated with increased Parental longevity (combined parental attained age, Martingale residuals) (β=0.015). [GWAS Catalog]
- rs11066320 Nutrition imported
- G allele associated with decreased risk of Hypothyroidism (OR=0.14). [GWAS Catalog]
- rs11066325 Health risk imported
- C allele associated with slightly increased risk of HDL cholesterol levels (OR=1.37). [GWAS Catalog]
9 further PTPN11 variants in the knowledge base have only a brief annotation and are not listed here.
See your own PTPN11 genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my PTPN11 variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my PTPN11 variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.