rs10490924 ARMS2/HTRA1
ARMS2 A69S homozygous. Strong risk factor for AMD, especially wet AMD.
What is rs10490924?
rs10490924 is a single-nucleotide polymorphism (SNP) in the ARMS2/HTRA1 gene (Age-related maculopathy susceptibility 2 / HTRA1). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as TT. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs10490924 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| TT | high | ARMS2 A69S homozygous. Strong risk factor for AMD, especially wet AMD. | 88% |
| GT / TG | elevated | Increased AMD risk. ARMS2 variant carrier. | 85% |
| GG | typical / lower | Typical AMD risk at ARMS2 locus. | 88% |
How common is the T allele of rs10490924?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 22.0% |
|---|---|
| East Asian | 37.0% |
| African | 16.0% |
| South Asian | 32.0% |
| Admixed American | 20.0% |
| Global | 25.0% |
Which drugs have annotations for rs10490924?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| bevacizumab | Efficacy | 3 |
Is rs10490924 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs10490924 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.