rs10757274 9p21.3
Increased coronary heart disease risk. Second independent signal at 9p21.3 locus.
What is rs10757274?
rs10757274 is a single-nucleotide polymorphism (SNP) in the 9p21.3 gene (9p21.3 coronary artery disease locus). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as GG. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs10757274 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| GG | elevated | Increased coronary heart disease risk. Second independent signal at 9p21.3 locus. | 88% |
| AG / GA | slightly elevated | Moderately increased CHD risk. | 85% |
| AA | typical / lower | Typical CHD risk at this locus. | 88% |
How common is the G allele of rs10757274?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 49.0% |
|---|---|
| East Asian | 43.0% |
| African | 27.0% |
| South Asian | 48.0% |
| Admixed American | 42.0% |
| Global | 42.0% |
Which drugs have annotations for rs10757274?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| Antiinflammatory agents | Toxicity | 3 |
| non-steroids | Toxicity | 3 |
Is rs10757274 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs10757274 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.