rs11591147 PCSK9
Homozygous risk allele (G). Associated with: Abdominal aortic aneurysm; Apolipoprotein A1 levels; Apolipoprotein B levels
What is rs11591147?
rs11591147 is a single-nucleotide polymorphism (SNP) in the PCSK9 gene. Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as GG. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs11591147 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| GG | elevated | Homozygous risk allele (G). Associated with: Abdominal aortic aneurysm; Apolipoprotein A1 levels; Apolipoprotein B levels | 65% |
Which drugs have annotations for rs11591147?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| HMG-CoA reductase inhibitors | Efficacy | 3 |
Is rs11591147 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PharmGKB:3
- Drug:HMG-CoA reductase inhibitors
- Type:Efficacy
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs11591147 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.