rs12591786 RORA-AS1, RORA
T allele associated with increased Triglycerides to Total Lipids in Large HDL percentage (β=0.020). [GWAS Catalog]
What is rs12591786?
rs12591786 is a single-nucleotide polymorphism (SNP) in the RORA-AS1, RORA gene. Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as TT. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs12591786 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| TT | typical | T allele associated with increased Triglycerides to Total Lipids in Large HDL percentage (β=0.020). [GWAS Catalog] | 75% |
| CC | typical | C allele associated with increased Caffeine consumption from tea (β=0.020). [GWAS Catalog] | 65% |
Is rs12591786 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PubMed 33287642
- GWAS Catalog
- GCST011124
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs12591786 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.