rs13266634 SLC30A8
SLC30A8 Arg325Trp. Increased T2D risk; affects zinc transport in pancreatic beta cells.
What is rs13266634?
rs13266634 is a single-nucleotide polymorphism (SNP) in the SLC30A8 gene (Solute carrier family 30 member 8 (zinc transporter 8)). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as CC. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs13266634 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| CC | slightly elevated | SLC30A8 Arg325Trp. Increased T2D risk; affects zinc transport in pancreatic beta cells. | 80% |
| CT / TC | typical | Intermediate T2D risk at SLC30A8. | 77% |
| TT | typical / lower | Protective allele at SLC30A8. Reduced T2D risk. | 80% |
How common is the C allele of rs13266634?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 30.0% |
|---|---|
| East Asian | 46.0% |
| African | 7.0% |
| South Asian | 26.0% |
| Admixed American | 22.0% |
| Global | 27.0% |
Which drugs have annotations for rs13266634?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| repaglinide | Efficacy | 3 |
| insulin recombinant | Efficacy | 3 |
| zinc acetate | Efficacy | 3 |
Is rs13266634 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs13266634 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.