rs1426654 SLC24A5
SLC24A5 Thr111Ala. Lighter skin pigmentation variant. Nearly fixed in European populations.
What is rs1426654?
rs1426654 is a single-nucleotide polymorphism (SNP) in the SLC24A5 gene (Solute carrier family 24 member 5 (skin pigmentation)). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as AA. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs1426654 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| AA | typical / lower | SLC24A5 Thr111Ala. Lighter skin pigmentation variant. Nearly fixed in European populations. | 92% |
| AG / GA | typical / lower | Heterozygous. Mixed ancestry signal for skin pigmentation. | 78% |
| GG | typical / lower | Ancestral SLC24A5 variant. Common in African and East Asian populations. | 90% |
How common is the A allele of rs1426654?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 99.9% |
|---|---|
| East Asian | 0.1% |
| African | 1.0% |
| South Asian | 60.0% |
| Admixed American | 55.0% |
| Global | 40.0% |
Is rs1426654 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs1426654 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.