rs1447295 8q24
Increased risk for prostate cancer. 8q24 is a major prostate cancer susceptibility locus.
What is rs1447295?
rs1447295 is a single-nucleotide polymorphism (SNP) in the 8q24 gene (8q24 cancer susceptibility region). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as AA. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs1447295 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| AA | elevated | Increased risk for prostate cancer. 8q24 is a major prostate cancer susceptibility locus. | 85% |
| CA / AC | slightly elevated | Moderately increased prostate cancer risk. | 82% |
| CC | typical / lower | Typical prostate cancer risk at this locus. | 85% |
How common is the A allele of rs1447295?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 10.0% |
|---|---|
| East Asian | 29.0% |
| African | 46.0% |
| South Asian | 15.0% |
| Admixed American | 18.0% |
| Global | 22.0% |
Is rs1447295 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs1447295 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.