rs199499 WNT3
C allele associated with increased Alcohol consumption (drinks per month) (UKB data field 1578, 4424) (β=0.023). [GWAS Catalog]
What is rs199499?
rs199499 is a single-nucleotide polymorphism (SNP) in the WNT3 gene. Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as CC. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs199499 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| CC | typical | C allele associated with increased Alcohol consumption (drinks per month) (UKB data field 1578, 4424) (β=0.023). [GWAS Catalog] | 75% |
| TT | typical | T allele associated with marginally increased risk of Osteoarthritis (with total hip replacement) (OR=1.06). [GWAS Catalog] | 65% |
Is rs199499 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PubMed 40205036
- GWAS Catalog
- GCST90566802
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs199499 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.