rs2108622 CYP4F2
CYP4F2 V433M homozygous. Higher warfarin dose required due to reduced vitamin K metabolism.
What is rs2108622?
rs2108622 is a single-nucleotide polymorphism (SNP) in the CYP4F2 gene (Cytochrome P450 4F2). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as TT. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs2108622 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| TT | increased | CYP4F2 V433M homozygous. Higher warfarin dose required due to reduced vitamin K metabolism. | 82% |
| CT / TC | increased | CYP4F2 V433M carrier. Slightly higher warfarin dose may be needed. | 78% |
| CC | typical | Normal CYP4F2 function. Standard warfarin dosing. | 82% |
How common is the T allele of rs2108622?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 26.0% |
|---|---|
| East Asian | 24.0% |
| African | 8.0% |
| South Asian | 28.0% |
| Admixed American | 22.0% |
| Global | 22.0% |
Which drugs have annotations for rs2108622?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| warfarin | Dosage, Metabolism/PK, Other, Efficacy | 1A |
| acenocoumarol | Dosage, Metabolism/PK, Other, Efficacy | 1A |
| vitamin e | Dosage, Metabolism/PK | 1A |
Is rs2108622 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs2108622 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.