rs261334 ALDH1A2, LIPC
C allele associated with decreased risk of Triglycerides to total lipids ratio in chylomicrons and extremely large VLDL (OR=0.16). [GWAS Catalog]
What is rs261334?
rs261334 is a single-nucleotide polymorphism (SNP) in the ALDH1A2, LIPC gene. Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as CC. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs261334 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| CC | typical / lower | C allele associated with decreased risk of Triglycerides to total lipids ratio in chylomicrons and extremely large VLDL (OR=0.16). [GWAS Catalog] | 95% |
| GG | typical / lower | G allele associated with decreased risk of Saturated fatty acid levels (OR=0.11). [GWAS Catalog] | 95% |
Is rs261334 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PubMed 35213538
- GWAS Catalog
- GCST90092980
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs261334 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.