rs2717018 ACTG1P22 - VRK2
T allele associated with increased Problematic alcohol use (MTAG) (β=0.017). [GWAS Catalog]
What is rs2717018?
rs2717018 is a single-nucleotide polymorphism (SNP) in the ACTG1P22 - VRK2 gene. Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as TT. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs2717018 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| TT | typical | T allele associated with increased Problematic alcohol use (MTAG) (β=0.017). [GWAS Catalog] | 75% |
Is rs2717018 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PubMed 32451486
- GWAS Catalog
- GCST010544
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs2717018 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.