rs3135388 HLA-DRB1
HLA-DRB1*15:01 tag SNP. Strong risk factor for multiple sclerosis (3x risk).
What is rs3135388?
rs3135388 is a single-nucleotide polymorphism (SNP) in the HLA-DRB1 gene (HLA class II DR beta 1). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as AA. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs3135388 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| AA | elevated | HLA-DRB1*15:01 tag SNP. Strong risk factor for multiple sclerosis (3x risk). | 88% |
| AG / GA | slightly elevated | Carrier of MS risk allele. Moderately increased MS risk. | 85% |
| GG | typical / lower | Typical MS risk at HLA-DRB1 locus. | 88% |
How common is the A allele of rs3135388?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 15.0% |
|---|---|
| East Asian | 1.0% |
| African | 3.0% |
| South Asian | 5.0% |
| Admixed American | 8.0% |
| Global | 7.0% |
Is rs3135388 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs3135388 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.