rs4720837 MAFK
C allele associated with increased Caudate iron levels (R2* MRI) (β=0.056). [GWAS Catalog]
What is rs4720837?
rs4720837 is a single-nucleotide polymorphism (SNP) in the MAFK gene. Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as CC. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs4720837 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| CC | typical | C allele associated with increased Caudate iron levels (R2* MRI) (β=0.056). [GWAS Catalog] | 75% |
| AA | increased | A allele associated with increased Standing height (UKB data field 50) (β=0.008). [GWAS Catalog] | 75% |
Is rs4720837 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PubMed 39789286
- GWAS Catalog
- GCST90468178
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs4720837 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.