rs4986893 CYP2C19
Drug response
What is rs4986893?
rs4986893 is a single-nucleotide polymorphism (SNP) in the CYP2C19 gene (Cytochrome P450 2C19). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as CT. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs4986893 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|
Which drugs have annotations for rs4986893?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| phenytoin | Toxicity, Metabolism/PK, Efficacy, Dosage | 3 |
| ethambutol | Toxicity, Metabolism/PK, Efficacy, Dosage | 3 |
| isoniazid | Toxicity, Metabolism/PK | 3 |
Is rs4986893 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PharmGKB:3
- Drug:phenytoin
- Type:Toxicity
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs4986893 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.