rs6658257 DR1
G allele associated with increased Cholesterol to Total Lipids in Small HDL percentage (β=0.020). [GWAS Catalog]
What is rs6658257?
rs6658257 is a single-nucleotide polymorphism (SNP) in the DR1 gene. Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as GG. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs6658257 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| GG | typical | G allele associated with increased Cholesterol to Total Lipids in Small HDL percentage (β=0.020). [GWAS Catalog] | 85% |
| AA | typical | A allele associated with increased Omega-6 fatty acid percentage of total fatty acids (β=0.021). [GWAS Catalog] | 75% |
Is rs6658257 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PubMed 41044249
- GWAS Catalog
- GCST90501235
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs6658257 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.