rs6774721 USP4 - GPX1
A allele associated with substantially increased risk of Intelligence (OR=7.12). [GWAS Catalog]
What is rs6774721?
rs6774721 is a single-nucleotide polymorphism (SNP) in the USP4 - GPX1 gene. Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as AA. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs6774721 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| AA | high | A allele associated with substantially increased risk of Intelligence (OR=7.12). [GWAS Catalog] | 80% |
| CC | typical / lower | C allele associated with decreased risk of Systolic blood pressure (OR=0.25). [GWAS Catalog] | 70% |
Is rs6774721 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PubMed 30224653
- GWAS Catalog
- GCST006624
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs6774721 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.