rs6983267 8q24/MYC
Increased risk for colorectal cancer. 8q24 region near MYC oncogene.
What is rs6983267?
rs6983267 is a single-nucleotide polymorphism (SNP) in the 8q24/MYC gene (8q24 region near MYC). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as GG. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs6983267 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| GG | slightly elevated | Increased risk for colorectal cancer. 8q24 region near MYC oncogene. | 82% |
| GT / TG | typical | Intermediate colorectal cancer risk. | 78% |
| TT | typical / lower | Lower colorectal cancer risk at this locus. | 82% |
How common is the G allele of rs6983267?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 50.0% |
|---|---|
| East Asian | 33.0% |
| African | 48.0% |
| South Asian | 45.0% |
| Admixed American | 47.0% |
| Global | 45.0% |
Which drugs have annotations for rs6983267?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| Platinum compounds | Efficacy | 3 |
Is rs6983267 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs6983267 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.