rs77697917 SOST - DUSP3

C allele associated with decreased risk of High density lipoprotein cholesterol levels (OR=0.15). [GWAS Catalog]

Imported from public databases · not individually reviewed Health risk · Risk / effect allele: C · dbSNP

What is rs77697917?

rs77697917 is a single-nucleotide polymorphism (SNP) in the SOST - DUSP3 gene. Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as CC. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.

What does each rs77697917 genotype mean?

Genotype	Association	What the evidence says	Confidence
CC	typical / lower	C allele associated with decreased risk of High density lipoprotein cholesterol levels (OR=0.15). [GWAS Catalog]	90%
TT	typical	T allele associated with increased Monounsaturated fatty acids (16:1, 18:1) levels (β=0.085). [GWAS Catalog]	75%

Is rs77697917 on 23andMe and AncestryDNA chips?

Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.

Sources

See your own rs77697917 genotype
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs77697917 and what does it mean for me?”

Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.