PhenoAge Age Acceleration
PhenoAge acceleration is PhenoAge minus chronological age, in years. Because PhenoAge was trained on clinical markers of mortality rather than on age itself, its acceleration tracks physiological wear — inflammation, glucose control, kidney and liver function — more closely than the first-generation clocks, and it responds to lifestyle change within months.
Bands are the ones Orviva uses to colour a result; they come from the source publication's cohort and are not diagnostic thresholds.
What is PhenoAge Age Acceleration?
PhenoAge acceleration is PhenoAge minus chronological age, in years. Because PhenoAge was trained on clinical markers of mortality rather than on age itself, its acceleration tracks physiological wear — inflammation, glucose control, kidney and liver function — more closely than the first-generation clocks, and it responds to lifestyle change within months.
What does a high or low PhenoAge Age Acceleration mean?
A positive value means the methylation pattern reads older than chronological age; negative, younger. Values between -3 and 3 years are within the clock's noise and should not be over-read. Sustained positive acceleration beyond the noise band is associated with higher disease and mortality risk at the population level.
Which interventions have been shown to change PhenoAge Age Acceleration?
| Intervention | Duration | Mean change | Evidence | Source |
|---|---|---|---|---|
| Caloric Restriction (CALERIE-2) | 24 months | -0.25 y (n=220) | high | Waziry et al. 2023 Nature Aging — CALERIE-2 RCT |
| Aerobic exercise (~150 min / week) | 6 months | -0.5 y (n=80) | moderate | Fitzgerald et al. 2021 Aging |
| Mediterranean diet | 18 months | -0.8 y (n=120) | moderate | Yaskolka-Meir et al. 2021 DIRECT-PLUS trial |
References
- Levine et al. 2018 — An epigenetic biomarker of aging for lifespan and healthspan (Aging) — https://doi.org/10.18632/aging.101414
Upload an Illumina 450k / EPIC or WeGene methylation CSV → · Ask G2: “What is my PhenoAge Age Acceleration and how has it changed?”
Epigenetic clocks are research-grade estimates with a test-retest noise of several years. A single result is a snapshot, not a verdict; trends over repeated samples are what carry information. For general education only — not a diagnosis or a substitute for medical advice.