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Epigenetic clocks and methylation scores, explained

What each DNA-methylation measure Orviva computes actually is, what a high or low value means, which published interventions moved it, and the papers behind it.

Epigenetic clocks

Horvath DNAm AgeHorvath 生物年龄Hannum DNAm AgeHannum 生物年龄PhenoAge表型年龄 PhenoAgeDunedinPACE衰老速率 DunedinPACE

Age acceleration

Horvath Age AccelerationHorvath 年龄加速PhenoAge Age AccelerationPhenoAge 年龄加速

Methylation risk scores

Smoking Exposure MRS吸烟甲基化暴露评分Epi-CRP EpiScoreEpi-CRP 炎症评分

Protein EpiScores

Adiponectin EpiScore脂联素 EpiScoreSHBG EpiScore性激素结合球蛋白 EpiScoreMyeloperoxidase EpiScore髓过氧化物酶 EpiScoreMMP-9 EpiScoreMMP-9 EpiScoreTNF sR-II EpiScoreTNF sR-II EpiScoreResistin EpiScore抵抗素 EpiScoreVCAM-1 EpiScoreVCAM-1 EpiScoreβ2-Microglobulin EpiScoreβ2-微球蛋白 EpiScore

Immune cell composition

CD4+ T cellsCD4+ T 细胞比例CD8+ T cellsCD8+ T 细胞比例Natural Killer cellsNK 细胞比例B cellsB 细胞比例Monocytes单核细胞比例Granulocytes粒细胞比例CD4+ T cells — naiveCD4+ T 初始细胞比例CD4+ T cells — memoryCD4+ T 记忆细胞比例CD8+ T cells — naiveCD8+ T 初始细胞比例CD8+ T cells — memoryCD8+ T 记忆细胞比例T regulatory cells调节性 T 细胞比例 (Treg)B cells — naiveB 初始细胞比例B cells — memoryB 记忆细胞比例Neutrophils中性粒细胞比例Eosinophils嗜酸性粒细胞比例Basophils嗜碱性粒细胞比例

Epigenetic clocks are research-grade estimates with a test-retest noise of several years. A single result is a snapshot, not a verdict; trends over repeated samples are what carry information. For general education only — not a diagnosis or a substitute for medical advice.