Horvath DNAm Age
Horvath's pan-tissue epigenetic clock — a weighted sum of β values at 353 CpG sites, passed through a piecewise log/linear transform, estimates chronological age across almost any human tissue.
What is Horvath DNAm Age?
Horvath's pan-tissue epigenetic clock — a weighted sum of β values at 353 CpG sites, passed through a piecewise log/linear transform, estimates chronological age across almost any human tissue.
What does a high or low Horvath DNAm Age mean?
A clock outputs a methylation age in years. On its own it is neither high nor low; what carries information is the gap to chronological age (see the matching age-acceleration indicator) and how the value moves between repeated samples.
References
- Horvath 2013 — DNA methylation age of human tissues and cell types (Genome Biology) — https://doi.org/10.1186/gb-2013-14-10-r115
- Horvath & Raj 2018 — DNA methylation-based biomarkers and the epigenetic clock theory of ageing (Nat Rev Genet) — https://doi.org/10.1038/s41576-018-0004-3
Upload an Illumina 450k / EPIC or WeGene methylation CSV → · Ask G2: “What is my Horvath DNAm Age and how has it changed?”
Epigenetic clocks are research-grade estimates with a test-retest noise of several years. A single result is a snapshot, not a verdict; trends over repeated samples are what carry information. For general education only — not a diagnosis or a substitute for medical advice.