DunedinPACE
DunedinPACE — 173 CpG single-sample estimator of the *pace* of biological aging (years of biological aging per chronological year). 1.0 = normal pace; > 1.05 is accelerated.
Bands are the ones Orviva uses to colour a result; they come from the source publication's cohort and are not diagnostic thresholds.
What is DunedinPACE?
DunedinPACE — 173 CpG single-sample estimator of the *pace* of biological aging (years of biological aging per chronological year). 1.0 = normal pace; > 1.05 is accelerated.
What does a high or low DunedinPACE mean?
DunedinPACE is a pace, not an age: 1.0 means the body is ageing one biological year per calendar year, 1.2 means 20% faster, 0.9 means 10% slower. It responds to lifestyle change faster than the absolute-age clocks, which is why it is the usual outcome measure in intervention trials.
Which interventions have been shown to change DunedinPACE?
| Intervention | Duration | Mean change | Evidence | Source |
|---|---|---|---|---|
| Caloric Restriction (CALERIE-2) | 24 months | -0.03 (n=220) | high | Waziry et al. 2023 Nature Aging — CALERIE-2 RCT |
| Rapamycin | 12 months | -0.02 (n=40) | preliminary | Preliminary PEARL trial reports 2023 |
| NMN supplementation | 3 months | -0.01 (n=30) | low | Yoshino 2021 Science + subsequent small RCTs |
| NR supplementation | 3 months | -0.01 (n=24) | low | Martens et al. 2018 Nat Commun |
| Aerobic exercise (~150 min / week) | 6 months | -0.04 (n=80) | moderate | Fitzgerald et al. 2021 Aging |
| Resistance training | 6 months | -0.02 (n=60) | moderate | Fitzgerald et al. 2021 + meta-analyses |
References
- Belsky et al. 2022 — DunedinPACE: DNA methylation biomarker of the pace of aging (eLife) — https://doi.org/10.7554/eLife.73420
Upload an Illumina 450k / EPIC or WeGene methylation CSV → · Ask G2: “What is my DunedinPACE and how has it changed?”
Epigenetic clocks are research-grade estimates with a test-retest noise of several years. A single result is a snapshot, not a verdict; trends over repeated samples are what carry information. For general education only — not a diagnosis or a substitute for medical advice.