Epi-CRP EpiScore
Epi-CRP EpiScore — 100 CpG methylation-based predictor of chronic systemic inflammation (Gadd 2022 eLife, KORA-trained). Output is a z-like index centered near 0 in healthy adults, not calibrated to mg/L. Proxy for long-term average inflammation; cross-reference with plasma hs-CRP when available.
Bands are the ones Orviva uses to colour a result; they come from the source publication's cohort and are not diagnostic thresholds.
What is Epi-CRP EpiScore?
Epi-CRP EpiScore — 100 CpG methylation-based predictor of chronic systemic inflammation (Gadd 2022 eLife, KORA-trained). Output is a z-like index centered near 0 in healthy adults, not calibrated to mg/L. Proxy for long-term average inflammation; cross-reference with plasma hs-CRP when available.
What does a high or low Epi-CRP EpiScore mean?
This is a z-like index centred near 0 (score), not a blood concentration. -0.3 to 0.3 is the typical band. It reflects the methylation footprint of long-term average exposure or protein level, and complements rather than replaces a single blood test.
References
- Gadd et al. 2022 — Epigenetic scores for the circulating proteome as tools for disease prediction (eLife) — https://doi.org/10.7554/eLife.71802
- Stevenson et al. 2020 — Trajectories of inflammatory biomarkers over the eighth decade (Clin Epigenet) — https://doi.org/10.1186/s13148-020-00864-y
Upload an Illumina 450k / EPIC or WeGene methylation CSV → · Ask G2: “What is my Epi-CRP EpiScore and how has it changed?”
Epigenetic clocks are research-grade estimates with a test-retest noise of several years. A single result is a snapshot, not a verdict; trends over repeated samples are what carry information. For general education only — not a diagnosis or a substitute for medical advice.