β2-Microglobulin EpiScore
Methylation-predicted β2-microglobulin. Tracks kidney function decline and chronic immune activation.
Typical reference band: -0.5 – 0.5 score
Bands are the ones Orviva uses to colour a result; they come from the source publication's cohort and are not diagnostic thresholds.
Bands are the ones Orviva uses to colour a result; they come from the source publication's cohort and are not diagnostic thresholds.
What is β2-Microglobulin EpiScore?
Methylation-predicted β2-microglobulin. Tracks kidney function decline and chronic immune activation.
What does a high or low β2-Microglobulin EpiScore mean?
This is a z-like index centred near 0 (score), not a blood concentration. -0.5 to 0.5 is the typical band. It reflects the methylation footprint of long-term average exposure or protein level, and complements rather than replaces a single blood test.
References
- Gadd et al. 2022 — Epigenetic scores for the circulating proteome as tools for disease prediction (eLife) — https://doi.org/10.7554/eLife.71802
- Gadd EpiScores weights (KORA training cohort, MIT) — https://github.com/DanniGadd/EpiScores-for-protein-levels
Compute your own β2-Microglobulin EpiScore from a methylation array
Upload an Illumina 450k / EPIC or WeGene methylation CSV → · Ask G2: “What is my β2-Microglobulin EpiScore and how has it changed?”
Upload an Illumina 450k / EPIC or WeGene methylation CSV → · Ask G2: “What is my β2-Microglobulin EpiScore and how has it changed?”
Epigenetic clocks are research-grade estimates with a test-retest noise of several years. A single result is a snapshot, not a verdict; trends over repeated samples are what carry information. For general education only — not a diagnosis or a substitute for medical advice.