Smoking Exposure MRS
AHRR (aryl hydrocarbon receptor repressor) methylation score. cg05575921 is the single strongest methylation biomarker of tobacco exposure in blood. Scale: < 1 never-smoker, 1–3 former, 3–6 current, > 6 heavy.
What is Smoking Exposure MRS?
AHRR (aryl hydrocarbon receptor repressor) methylation score. cg05575921 is the single strongest methylation biomarker of tobacco exposure in blood. Scale: < 1 never-smoker, 1–3 former, 3–6 current, > 6 heavy.
What does a high or low Smoking Exposure MRS mean?
This is a z-like index centred near 0 (score), not a blood concentration. It reflects the methylation footprint of long-term average exposure or protein level, and complements rather than replaces a single blood test.
References
- Philibert et al. 2020 — A quantitative epigenetic approach for the assessment of cigarette consumption (Front Psychiatry) — https://doi.org/10.3389/fpsyt.2020.00167
- Joehanes et al. 2016 — Epigenetic signatures of cigarette smoking (Circ Cardiovasc Genet) — https://doi.org/10.1161/CIRCGENETICS.116.001506
Upload an Illumina 450k / EPIC or WeGene methylation CSV → · Ask G2: “What is my Smoking Exposure MRS and how has it changed?”
Epigenetic clocks are research-grade estimates with a test-retest noise of several years. A single result is a snapshot, not a verdict; trends over repeated samples are what carry information. For general education only — not a diagnosis or a substitute for medical advice.