BCMO1 Beta-carotene oxygenase 1 (BCO1)
BCMO1 (Beta-carotene oxygenase 1 (BCO1)): 2 variants described, covering nutrition; nutrient interactions.
Which BCMO1 variants does Orviva describe?
- rs12934922 Nutrition
- BCMO1 R267S homozygous. Reduced beta-carotene conversion; combined with rs7501331 can cause ~57% reduction.
- rs7501331 Nutrition
- Significantly reduced beta-carotene to vitamin A conversion (~69% reduction). Preformed vitamin A (retinol) recommended.
Which nutrients interact with BCMO1 variants?
- retinol strong evidence
- BCMO1 variants reduce β-carotene to retinol conversion by up to 69%
Often considered alongside: zinc, vitamin E.
Lab markers that reflect this pathway: RETINOL.
Dose ranges are deliberately not shown here; they depend on genotype, current levels and other medicines.
See your own BCMO1 genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my BCMO1 variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my BCMO1 variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.