rs7501331 BCMO1
Significantly reduced beta-carotene to vitamin A conversion (~69% reduction). Preformed vitamin A (retinol) recommended.
What is rs7501331?
rs7501331 is a single-nucleotide polymorphism (SNP) in the BCMO1 gene (Beta-carotene oxygenase 1 (BCO1)). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as TT. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs7501331 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| TT | increased | Significantly reduced beta-carotene to vitamin A conversion (~69% reduction). Preformed vitamin A (retinol) recommended. | 85% |
| CT / TC | increased | Moderately reduced beta-carotene conversion (~32% reduction). | 82% |
| CC | typical | Normal beta-carotene to vitamin A conversion. | 85% |
How common is the T allele of rs7501331?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 24.0% |
|---|---|
| East Asian | 25.0% |
| African | 18.0% |
| South Asian | 22.0% |
| Admixed American | 22.0% |
| Global | 22.0% |
Is rs7501331 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs7501331 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.