FUT2 Fucosyltransferase 2 (secretor status)
FUT2 (Fucosyltransferase 2 (secretor status)): 21 variants described, covering trait, health risk, nutrition, drug response; nutrient interactions.
Which FUT2 variants does Orviva describe?
- rs602662 Nutrition
- FUT2 non-secretor. Reduced vitamin B12 absorption from food. B12 supplementation recommended.
- rs35106244 Nutrition imported
- T allele associated with increased LDL cholesterol (β=0.029). [GWAS Catalog]
- rs516316 Drug response imported
- G allele associated with increased LDL cholesterol levels (β=0.030). [GWAS Catalog]
- rs679574 Nutrition imported
- G allele associated with increased Cholesterol levels (UKB data field 30690) (β=0.031). [GWAS Catalog]
17 further FUT2 variants in the knowledge base have only a brief annotation and are not listed here.
Which nutrients interact with FUT2 variants?
- methylcobalamin moderate evidence
- FUT2 non-secretor status reduces gut B12 absorption efficiency
Often considered alongside: methylfolate.
Lab markers that reflect this pathway: B12, MMA, HCY.
Dose ranges are deliberately not shown here; they depend on genotype, current levels and other medicines.
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my FUT2 variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.