rs679574 FUT2
G allele associated with increased Cholesterol levels (UKB data field 30690) (β=0.031). [GWAS Catalog]
What is rs679574?
rs679574 is a single-nucleotide polymorphism (SNP) in the FUT2 gene (Fucosyltransferase 2 (secretor status)). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as GG. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs679574 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| GG | typical | G allele associated with increased Cholesterol levels (UKB data field 30690) (β=0.031). [GWAS Catalog] | 90% |
| CC | typical / lower | C allele associated with decreased risk of Other vitamin B12 deficiency anemia (PheCode 281.12) (OR=0.17). [GWAS Catalog] | 90% |
Is rs679574 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PubMed 39024449
- GWAS Catalog
- GCST90479962
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs679574 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.