SLCO1B1 Solute carrier organic anion transporter 1B1 (statin uptake)
SLCO1B1 (Solute carrier organic anion transporter 1B1 (statin uptake)): 36 variants described, covering health risk, drug response, trait, nutrition.
Which SLCO1B1 variants does Orviva describe?
- rs4149056 Drug response
- SLCO1B1*5 homozygous. High risk of simvastatin-induced myopathy. Consider alternative statin or lower dose.
- rs12317268 Health risk imported
- G allele associated with slightly decreased risk of Urinary metabolite levels in chronic kidney disease (OR=0.98). [GWAS Catalog]
- rs1871395 Health risk imported
- A allele associated with increased Sex hormone-binding globulin levels adjusted for BMI (β=0.032). [GWAS Catalog]
- rs2306283 Drug response imported
- Normal SLCO1B1 function at this position.
- rs67981690 Nutrition imported
- G allele associated with increased Triglycerides in medium VLDL (β=0.040). [GWAS Catalog]
- rs73079476 Nutrition imported
- C allele associated with increased Triglycerides to Total Lipids in Very Small VLDL percentage (β=0.030). [GWAS Catalog]
30 further SLCO1B1 variants in the knowledge base have only a brief annotation and are not listed here.
See your own SLCO1B1 genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my SLCO1B1 variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my SLCO1B1 variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.