rs4149056 SLCO1B1
SLCO1B1*5 homozygous. High risk of simvastatin-induced myopathy. Consider alternative statin or lower dose.
What is rs4149056?
rs4149056 is a single-nucleotide polymorphism (SNP) in the SLCO1B1 gene (Solute carrier organic anion transporter 1B1 (statin uptake)). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as CC. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs4149056 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| CC | increased | SLCO1B1*5 homozygous. High risk of simvastatin-induced myopathy. Consider alternative statin or lower dose. | 90% |
| TC / CT | increased | SLCO1B1*5 carrier. Increased risk of statin side effects. | 87% |
| TT | typical | Normal SLCO1B1 function. Standard statin tolerance. | 90% |
How common is the C allele of rs4149056?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 15.0% |
|---|---|
| East Asian | 12.0% |
| African | 2.0% |
| South Asian | 4.0% |
| Admixed American | 9.0% |
| Global | 9.0% |
Which drugs have annotations for rs4149056?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| simvastatin | Metabolism/PK, Toxicity, Dosage, Efficacy, PD | 1A |
| simvastatin acid | Metabolism/PK, Toxicity, Dosage, Efficacy, PD | 1A |
Is rs4149056 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs4149056 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.