TCF7L2 Transcription factor 7-like 2
TCF7L2 (Transcription factor 7-like 2): 77 variants described, covering health risk, trait, drug response.
Which TCF7L2 variants does Orviva describe?
- rs7903146 Health risk
- Significantly increased risk for Type 2 Diabetes. TCF7L2 is the strongest common genetic risk factor for T2D.
- rs35198068 Health risk imported
- T allele associated with increased Body mass index (BMI, minimum, inv-normal transformed) (β=0.060). [GWAS Catalog]
75 further TCF7L2 variants in the knowledge base have only a brief annotation and are not listed here.
See your own TCF7L2 genotypes
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my TCF7L2 variants say about me?”
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What do my TCF7L2 variants say about me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.