rs7903146 TCF7L2
Significantly increased risk for Type 2 Diabetes. TCF7L2 is the strongest common genetic risk factor for T2D.
What is rs7903146?
rs7903146 is a single-nucleotide polymorphism (SNP) in the TCF7L2 gene (Transcription factor 7-like 2). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as TT. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs7903146 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| TT | high | Significantly increased risk for Type 2 Diabetes. TCF7L2 is the strongest common genetic risk factor for T2D. | 92% |
| CT / TC | slightly elevated | Moderately increased T2D risk due to one copy of TCF7L2 risk variant. | 88% |
| CC | typical / lower | Typical T2D risk at this locus. | 90% |
How common is the T allele of rs7903146?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 29.0% |
|---|---|
| East Asian | 3.0% |
| African | 29.0% |
| South Asian | 31.0% |
| Admixed American | 24.0% |
| Global | 23.0% |
Which drugs have annotations for rs7903146?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| cyclosporine | Toxicity, Efficacy | 3 |
| sirolimus | Toxicity, Efficacy | 3 |
| tacrolimus | Toxicity, Efficacy | 3 |
| sulfonamides | Toxicity, Efficacy | 3 |
| urea derivatives | Toxicity, Efficacy | 3 |
Is rs7903146 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs7903146 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.