rs1050828 G6PD
AA
What is rs1050828?
rs1050828 is a single-nucleotide polymorphism (SNP) in the G6PD gene (Glucose-6-phosphate dehydrogenase). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as 0. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs1050828 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| 0 | typical | AA | 85% |
| TT | elevated | Homozygous risk allele (T). Associated with: Anemia, nonspherocytic hemolytic, due to g6pd deficiency; phenotype not specified; Direct bilirubin levels | 65% |
| CC | typical | Normal G6PD function at this position. Standard drug dosing. | 90% |
| CT | increased | G6PD A- variant carrier. Risk of hemolytic anemia with oxidative drugs. Rasburicase contraindicated. | 90% |
Which drugs have annotations for rs1050828?
PharmGKB clinical annotations (level 1A is the strongest evidence, 4 the weakest):
| Drug | Annotation type | Evidence level |
|---|---|---|
| artesunate | Toxicity | 3 |
| primaquine | Toxicity | 3 |
| pyrimethamine | Toxicity | 3 |
| sulfadoxine | Toxicity | 3 |
| amodiaquine | Toxicity | 3 |
| chlorproguanil | Toxicity | 3 |
| dapsone | Toxicity | 3 |
Is rs1050828 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PharmGKB:3
- Drug:artesunate
- Type:Toxicity
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs1050828 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.