rs13083375 PPARG
G allele associated with increased Body mass index (BMI, minimum, inv-normal transformed) (β=0.040). [GWAS Catalog]
What is rs13083375?
rs13083375 is a single-nucleotide polymorphism (SNP) in the PPARG gene (Peroxisome proliferator-activated receptor gamma). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as GG. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs13083375 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| GG | increased | G allele associated with increased Body mass index (BMI, minimum, inv-normal transformed) (β=0.040). [GWAS Catalog] | 75% |
| TT | typical / lower | T allele associated with decreased risk of Fatty acid-binding protein, heart levels (OR=0.13). [GWAS Catalog] | 80% |
Is rs13083375 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PubMed 34648354
- GWAS Catalog
- GCST90247548
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs13083375 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.