rs1789882 ADH1B
A allele associated with increased Waist-hip ratio (β=0.016). [GWAS Catalog]
What is rs1789882?
rs1789882 is a single-nucleotide polymorphism (SNP) in the ADH1B gene (Alcohol dehydrogenase 1B). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as AA. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs1789882 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| AA | increased | A allele associated with increased Waist-hip ratio (β=0.016). [GWAS Catalog] | 75% |
| GG | slightly elevated | G allele associated with slightly increased risk of Alcohol dependence (OR=1.30). [GWAS Catalog] | 65% |
Is rs1789882 on 23andMe and AncestryDNA chips?
Chip coverage is not recorded for this variant. Orviva reports it when a raw-data file contains it directly or via a well-correlated proxy SNP, and says so when it does not.
Sources
- PubMed 30239722
- GWAS Catalog
- GCST008996
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs1789882 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.