rs2814778 DARC/ACKR1
Duffy-null phenotype. Provides resistance to P. vivax malaria. Nearly fixed in sub-Saharan African populations.
What is rs2814778?
rs2814778 is a single-nucleotide polymorphism (SNP) in the DARC/ACKR1 gene (Duffy antigen receptor for chemokines (ACKR1)). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as CC. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs2814778 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| CC | typical / lower | Duffy-null phenotype. Provides resistance to P. vivax malaria. Nearly fixed in sub-Saharan African populations. | 93% |
| CT / TC | typical / lower | Heterozygous Duffy antigen. Partial malaria resistance. | 88% |
| TT | typical / lower | Duffy-positive. Common in European and Asian populations. | 90% |
How common is the C allele of rs2814778?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 0.1% |
|---|---|
| East Asian | 0.1% |
| African | 97.0% |
| South Asian | 0.1% |
| Admixed American | 15.0% |
| Global | 20.0% |
Is rs2814778 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs2814778 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.