rs2981582 FGFR2
FGFR2 variant associated with increased breast cancer risk (1.26x per allele).
What is rs2981582?
rs2981582 is a single-nucleotide polymorphism (SNP) in the FGFR2 gene (Fibroblast growth factor receptor 2). Each person carries two copies, one from each parent, so a result is reported as a pair of letters such as AA. The table below describes what studies associate with each genotype; the association is statistical, across populations, and is not a diagnosis.
What does each rs2981582 genotype mean?
| Genotype | Association | What the evidence says | Confidence |
|---|---|---|---|
| AA | slightly elevated | FGFR2 variant associated with increased breast cancer risk (1.26x per allele). | 85% |
| AG / GA | typical | Intermediate breast cancer risk at FGFR2. | 82% |
| GG | typical / lower | Lower breast cancer risk at FGFR2 locus. | 85% |
How common is the A allele of rs2981582?
Minor-allele frequency by population (gnomAD / 1000 Genomes):
| European | 38.0% |
|---|---|
| East Asian | 55.0% |
| African | 44.0% |
| South Asian | 48.0% |
| Admixed American | 42.0% |
| Global | 45.0% |
Is rs2981582 on 23andMe and AncestryDNA chips?
Yes — it is genotyped directly on 23andMe V3, 23andMe V4, 23andMe V5, AncestryDNA V1, AncestryDNA V2. Orviva reads it from a raw-data export without imputation.
Sources
Upload your 23andMe, AncestryDNA or WeGene raw file → · Ask G2: “What is my genotype at rs2981582 and what does it mean for me?”
Genetic associations describe risk across populations, not a diagnosis for any one person. Most variants shift risk modestly and act alongside lifestyle, environment and other genes. Consumer DNA chips do not read every position and can be wrong at any single one. For general education only; talk to a clinician or genetic counsellor before acting on anything here, and never change a prescribed medicine without your prescriber.